In the original After the Bomb game supplement for TMNT:AOS and Heroes Unlimited, the background for the setting was that radiation and fallout from a nuclear war was what killed off the majority of the human race and created the mutations that led to the rise of mutant animals. Typical for a setting that was created in the 80s.
In 2nd Edition, the setting was moved from the 80's to a period somewhere in the middle of the 21st Century where bio-tech is as commonplace as home computers and smartphones. Now, instead of the animal mutations and human death being caused by nuclear armageddon, a genetic plague is to blame. There is still nuclear armageddon, but it's more responsible to the collapse of what little society was left behind.
Today, I found the attached video which describes how gene therapy today could be used to mess with genetics. Just imagine if someone were to patch something like this onto a flu virus and loosed it on the world.
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